CRLF2 anticorps

N° du produit ABIN2665445

Cet anticorps anti-CRLF2 est un anticorps Souris Monoclonal détectant CRLF2 dans FACS, IF, Dep, Func et IP. Adapté pour Humain.

Aperçu rapide pour CRLF2 anticorps (ABIN2665445)

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CRLF2 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Depletion (Dep), Functional Studies (Func), Immunoprecipitation (IP)

Clone: 1B4

Détail du produit anti-CRLF2 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CRLF2

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Autre désignation: TSLPR

Sujet: TSLP-R, also known as the thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, and IL-XR, is a type I membrane receptor that forms a functional heterodimeric complex with IL-7R to bind with TSLP. The TSLP-R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. TSLP-R has a predicted molecular weight approximately 40 kD, and has two isoforms reported that are produced by alternative splicing. The TSLP-R is expressed preferentially in myeloid cells, dendritic cells, and activated monocytes. It is weakly expressed in T cells. Expression has also been reported in heart, skeletal, muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLP-R and IL-7R) activates JAK2, STAT3, and STAT5 to stimulate cell proliferation. Ligand receptor interactions have been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergy diseases.